The invention provides a system and method for integrating petroleum system and geomechanical computer models for use in oil and gas exploration. In one embodiment, the invention provides a petroleum system model capable of analyzing data relating to a subterranean formation and calculating the geometry and geochemistry of each layer of the formation through geologic time. The present invention also provides a geomechanical model in communication with the petroleum system model such that information concerning each layer of the subterranean formation may be shared and cross-referenced as an iterative operation prior to the analysis of subsequent layers. At each step of the iterative operation, results are calculated, validated, and cross-referenced in order to produce improved reliability estimates of petroleum charge and mechanical seal integrity for the subterranean formation.