Invention Grant
- Patent Title: Method for the purification of mycophenolate mofetil
- Patent Title (中): 霉酚酸酯的纯化方法
-
Application No.: US12666846Application Date: 2008-06-24
-
Publication No.: US08273739B2Publication Date: 2012-09-25
- Inventor: Robertus Mattheus De Pater
- Applicant: Robertus Mattheus De Pater
- Applicant Address: NL Delft
- Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
- Current Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
- Current Assignee Address: NL Delft
- Agency: Nixon & Vanderhye P.C.
- Priority: EP07111199 20070627
- International Application: PCT/EP2008/058021 WO 20080624
- International Announcement: WO2009/000834 WO 20081231
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07D413/12

Abstract:
The present invention provides a method for the preparation of mycophenolate mofetil wherein mycophenolic acid or an amine salt of mycophenolic acid is esterified with 2-morpholinoethanol, the resulting mixture is extracted into water at a pH-value between 1.0 and 3.0, and mycophenolate mofetil is back-extracted in a water-immiscible solvent at a pH-value between 3.0 and 5.0.
Public/Granted literature
- US20100190785A1 METHOD FOR THE PURIFICATION OF MYCOPHENOLATE MOFETIL Public/Granted day:2010-07-29
Information query
IPC分类: