Invention Grant
US08273866B2 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
有权
使用化学修饰的短干扰核酸（SINA）的RNA干扰介导的基因表达抑制
- Patent Title: RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
- Patent Title (中): 使用化学修饰的短干扰核酸（SINA）的RNA干扰介导的基因表达抑制
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Application No.: US10720448Application Date: 2003-11-24
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Publication No.: US08273866B2Publication Date: 2012-09-25
- Inventor: James McSwiggen , Leonid Beigelman
- Applicant: James McSwiggen , Leonid Beigelman
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Peter Haeberli; David A. Muthard
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; A61K48/00
Abstract:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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