Invention Grant
- Patent Title: NK1 antagonists
- Patent Title (中): NK1拮抗剂
-
Application No.: US12967132Application Date: 2010-12-14
-
Publication No.: US08273895B2Publication Date: 2012-09-25
- Inventor: Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
- Applicant: Sunil Paliwal , Gregory A. Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan D. Arredondo , Michelle Laci Wrobleski , Anandan Palani
- Applicant Address: US FL Miami
- Assignee: Opko Health, Inc.
- Current Assignee: Opko Health, Inc.
- Current Assignee Address: US FL Miami
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Kristen C. Buteau
- Main IPC: C07D211/20
- IPC: C07D211/20 ; C07D207/12 ; A61K31/45 ; A61K31/451

Abstract:
A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
Public/Granted literature
- US20110098468A1 NK1 ANTAGONISTS Public/Granted day:2011-04-28
Information query