A noise reduction system and a noise reduction method are provided. The noise reduction system comprises a uni-directional microphone, an omni-directional microphone and a signal processing module. The signal processing module comprises an adaptive noise control (ANC) unit, a main noise reduction unit and an optimizing unit. The uni-directional microphone senses a first audio source to output a first audio signal, and the omni-directional microphone senses a second audio source to output a second audio signal. The ANC unit executes an adaptive noise control to output an estimated signal according to the first audio signal and the second audio signal. The main noise reduction unit executes a main noise reduction process to output a de-noise speech signal according to the estimated signal and the second audio signal. The optimizing unit executes an optimizing process to output an optimized speech signal according to the de-noise speech signal.