Invention Grant
US08277812B2 Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
有权
提供无T细胞抗原的IgG体液应答的免疫疗法
- Patent Title: Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
- Patent Title (中): 提供无T细胞抗原的IgG体液应答的免疫疗法
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Application No.: US12428408Application Date: 2009-04-22
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Publication No.: US08277812B2Publication Date: 2012-10-02
- Inventor: Matteo Iannacone , Frank Alexis , Pamela Basto , Elliott Ashley Moseman , Jinjun Shi , Robert S. Langer , Omid C. Farokhzad , Ulrich von Andrian , Elena Tonti
- Applicant: Matteo Iannacone , Frank Alexis , Pamela Basto , Elliott Ashley Moseman , Jinjun Shi , Robert S. Langer , Omid C. Farokhzad , Ulrich von Andrian , Elena Tonti
- Applicant Address: US MA Cambridge US MA Cambridge US MA Boston
- Assignee: Massachusetts Institute of Technology,President and Fellows of Harvard College,The Brigham and Women's Hospital, Inc.
- Current Assignee: Massachusetts Institute of Technology,President and Fellows of Harvard College,The Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Cambridge US MA Cambridge US MA Boston
- Agency: Pabst Patent Group LLP
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
Public/Granted literature
- US20100183727A1 Immunonanotherapeutics that Provide IgG Humoral Response Without T-Cell Antigen Public/Granted day:2010-07-22
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