Invention Grant
US08278061B2 Polymorphisms in the EGFR pathway as markers for cancer treatment
有权
EGFR途径中的多态性作为癌症治疗的标志物
- Patent Title: Polymorphisms in the EGFR pathway as markers for cancer treatment
- Patent Title (中): EGFR途径中的多态性作为癌症治疗的标志物
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Application No.: US12523517Application Date: 2008-01-17
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Publication No.: US08278061B2Publication Date: 2012-10-02
- Inventor: Heinz-Josef Lenz , Wu Zhang
- Applicant: Heinz-Josef Lenz , Wu Zhang
- Applicant Address: US CA Los Angeles
- Assignee: University of Southern California
- Current Assignee: University of Southern California
- Current Assignee Address: US CA Los Angeles
- Agency: Foley & Lardner LLP
- Agent Antoinette F. Konski; Alex Y. Nie
- International Application: PCT/US2008/000660 WO 20080117
- International Announcement: WO2008/088860 WO 20080724
- Main IPC: G01N33/574
- IPC: G01N33/574
Abstract:
The invention provides compositions and methods for identifying patients for single agent anti-EGFR therapy. The methods comprise determining the genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response. Patients identified as responsive are then treated with the appropriate therapy.
Public/Granted literature
- US20100172901A1 Polymorphisms in the EGFR Pathway as Markers for Cancer Treatment Public/Granted day:2010-07-08
Information query
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