Invention Grant
- Patent Title: GLP-1, exendin-4, peptide analogs and uses thereof
- Patent Title (中): GLP-1，毒蜥外泌肽-4，肽类似物及其用途
-
Application No.: US12317042Application Date: 2008-12-18
-
Publication No.: US08278272B2Publication Date: 2012-10-02
- Inventor: Nigel Greig , Josephine Egan , Maire Doyle , Harold Holloway , Tracy Ann Perry
- Applicant: Nigel Greig , Josephine Egan , Maire Doyle , Harold Holloway , Tracy Ann Perry
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee Address: US DC Washington
- Agency: Edwards Wildman Palmer LLP
- Agent Peter F. Corless
- Main IPC: A61K38/26
- IPC: A61K38/26 ; C07K14/605
Abstract:
The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects.
Public/Granted literature
- US20090253625A1 GLP-1, exendin-4, peptide analogs and uses thereof Public/Granted day:2009-10-08
Information query
IPC分类:
