Invention Grant
US08278284B2 Therapeutic agents for diseases associated with apoptotic degeneration in ocular tissue cells that use SIV-PEDF vectors
有权
与使用SIV-PEDF载体的眼组织细胞凋亡变性相关疾病的治疗剂
- Patent Title: Therapeutic agents for diseases associated with apoptotic degeneration in ocular tissue cells that use SIV-PEDF vectors
- Patent Title (中): 与使用SIV-PEDF载体的眼组织细胞凋亡变性相关疾病的治疗剂
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Application No.: US11884738Application Date: 2006-02-21
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Publication No.: US08278284B2Publication Date: 2012-10-02
- Inventor: Masanori Miyazaki , Yoshikazu Yonemitsu , Yasuhiro Ikeda , Katsuo Sueishi , Toshiaki Tabata , Akihiro Iida , Yasuji Ueda , Mamoru Hasegawa
- Applicant: Masanori Miyazaki , Yoshikazu Yonemitsu , Yasuhiro Ikeda , Katsuo Sueishi , Toshiaki Tabata , Akihiro Iida , Yasuji Ueda , Mamoru Hasegawa
- Agency: Clark & Elbing LLP
- Priority: JP2005-047951 20050223
- International Application: PCT/JP2006/303032 WO 20060221
- International Announcement: WO2006/090689 WO 20060831
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A01N63/00 ; C12P19/34

Abstract:
The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.
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