Invention Grant
US08278285B2 Gastric carcinoma gene ZNF312b, a protein translated from the gene, and a diagnostic kit and a screening method for anticancer agents using the same
有权
胃癌基因ZNF312b是从基因翻译的蛋白质，以及诊断试剂盒和使用其的抗癌剂的筛选方法
- Patent Title: Gastric carcinoma gene ZNF312b, a protein translated from the gene, and a diagnostic kit and a screening method for anticancer agents using the same
- Patent Title (中): 胃癌基因ZNF312b是从基因翻译的蛋白质，以及诊断试剂盒和使用其的抗癌剂的筛选方法
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Application No.: US12594843Application Date: 2008-08-06
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Publication No.: US08278285B2Publication Date: 2012-10-02
- Inventor: Nam-Soon Kim , In-Sung Song , Nang-Su Oh , So-Young Jeong , Ga-Hee Ha , Yeo-Jin Jeon , Jeong-Min Kim , Cheol-Hee Kim , Hyun-Taek Kim
- Applicant: Nam-Soon Kim , In-Sung Song , Nang-Su Oh , So-Young Jeong , Ga-Hee Ha , Yeo-Jin Jeon , Jeong-Min Kim , Cheol-Hee Kim , Hyun-Taek Kim
- Applicant Address: KR Daejon
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejon
- Agency: Licata & Tyrell P.C.
- Priority: KR10-2007-0078585 20070806; KR10-2007-0083814 20070821; KR10-2008-0073044 20080725
- International Application: PCT/KR2008/004566 WO 20080806
- International Announcement: WO2009/020346 WO 20090212
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04
Abstract:
The present invention relates to a diagnostic marker containing ZNF312b gene and the fragment thereof, a diagnostic method for stomach cancer and a screening method for stomach cancer inducers or inhibitors using the same. ZNF312b gene expression is specifically increased in stomach cancer. And the over-expression or the under-expression of the gene affects activation or inhibition of cell proliferation and tumor formation of a stomach cancer cell line and cell proliferation signal transduction system as well to induce stomach cancer at last. Therefore, ZNF312b marker gene can be effectively used for diagnosis of stomach cancer, construction of a stomach cancer animal model, prevention and treatment of stomach cancer and development of a stomach cancer specific anticancer agent.
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