Invention Grant
- Patent Title: Small molecule inhibition of intracellular transport
- Patent Title (中): 小分子抑制细胞内运输
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Application No.: US12645094Application Date: 2009-12-22
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Publication No.: US08278321B2Publication Date: 2012-10-02
- Inventor: David B. Haslam
- Applicant: David B. Haslam
- Applicant Address: US MO St. Louis
- Assignee: Washington University
- Current Assignee: Washington University
- Current Assignee Address: US MO St. Louis
- Agency: Polsinelli Shughart PC
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A01N43/40 ; A61K31/44 ; A61K31/445 ; C07D221/22 ; C07D221/06 ; C07D211/06
Abstract:
The present disclosure characterizes the activity of Golgicide A (GCA), as a potent, specific and reversible small molecule inhibitor of Golgi BFA resistance factor 1 (GBF1) function. A mutant GBF1 gene that is resistant to GCA is also described. Methods of using GCA and the GCA-resistant GBF1 gene are described including methods for modulating GBF1 activity for research and therapeutic purposes. Also described are compositions incorporating a GCA-resistant GBF1.
Public/Granted literature
- US20100159468A1 SMALL MOLECULE INHIBITION OF INTRACELLULAR TRANSPORT Public/Granted day:2010-06-24
Information query
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