Invention Grant
- Patent Title: PDE10 inhibitors and related compositions and methods
- Patent Title (中): PDE10抑制剂及相关组合物和方法
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Application No.: US12848766Application Date: 2010-08-02
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Publication No.: US08278327B2Publication Date: 2012-10-02
- Inventor: John E. Bergmann , Neil S. Cutshall , Rene Onrust , Hongkui Zeng , Jennifer Lynn Gage , Derek Johnston , Sándor Cseh , László Ürögdi , Ákos Papp
- Applicant: John E. Bergmann , Neil S. Cutshall , Rene Onrust , Hongkui Zeng , Jennifer Lynn Gage , Derek Johnston , Sándor Cseh , László Ürögdi , Ákos Papp
- Applicant Address: US WA Seattle
- Assignee: Omeros Corporation
- Current Assignee: Omeros Corporation
- Current Assignee Address: US WA Seattle
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/47 ; C07D215/00

Abstract:
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. The compounds have the general structure: wherein m, n, p, x, R, R1, R2, R3, R4, R5, A and B, are defined herein, including pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.
Public/Granted literature
- US20110021509A1 PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS Public/Granted day:2011-01-27
Information query
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