Invention Grant
- Patent Title: Inhibitors of Janus kinases
- Patent Title (中): Janus激酶抑制剂
-
Application No.: US12988705Application Date: 2009-04-09
-
Publication No.: US08278335B2Publication Date: 2012-10-02
- Inventor: Michelle R. Machacek , Andrew Haidle , Anna A. Zabierek , Kaleen M. Konrad , Michael D. Altman
- Applicant: Michelle R. Machacek , Andrew Haidle , Anna A. Zabierek , Kaleen M. Konrad , Michael D. Altman
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Laura M. Ginkel; David A. Muthard
- International Application: PCT/US2009/040008 WO 20090409
- International Announcement: WO2010/011375 WO 20100128
- Main IPC: A01N43/40
- IPC: A01N43/40 ; A61K31/44
Abstract:
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
Public/Granted literature
- US20110166129A1 INHIBITORS OF JANUS KINASES Public/Granted day:2011-07-07
Information query
IPC分类:
