Invention Grant
- Patent Title: Therapeutic compounds for blocking DNA synthesis of pox viruses
- Patent Title (中): 用于阻断痘病毒DNA合成的治疗化合物
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Application No.: US12537083Application Date: 2009-08-06
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Publication No.: US08278342B2Publication Date: 2012-10-02
- Inventor: Robert P. Ricciardi
- Applicant: Robert P. Ricciardi
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Pearl Cohen Zedek Latzer, LLP
- Agent Mark S. Cohen
- Main IPC: A61K31/40
- IPC: A61K31/40
Abstract:
This invention provides methods of inhibiting replication of a poxvirus by contacting a poxvirus with a compound having formula XVII which in turn reduce, inhibit, or abrogate poxvirus DNA polymerase activity and/or its interaction with its processivity factor. Formula XVII can be utilized to treat humans and animals suffering from a poxvirus infection. Pharmaceutical compositions for treating poxvirus infected subjects are also provided.
Public/Granted literature
- US20100035887A1 THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES Public/Granted day:2010-02-11
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