Invention Grant
- Patent Title: Quinolizidinone M1 receptor positive allosteric modulators
- Patent Title (中): 喹诺酮酮M1受体阳性变构调节剂
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Application No.: US13121423Application Date: 2009-09-29
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Publication No.: US08278453B2Publication Date: 2012-10-02
- Inventor: Scott D. Kuduk , Christina Ng Di Marco
- Applicant: Scott D. Kuduk , Christina Ng Di Marco
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; Gerard M. Devlin
- International Application: PCT/US2009/058763 WO 20090929
- International Announcement: WO2010/042347 WO 20100415
- Main IPC: C07D401/10
- IPC: C07D401/10 ; C07D401/14 ; C07D455/02
Abstract:
The present invention is directed to quinolizidinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20110178122A1 Quinolizidinone M1 Receptor Positive Allosteric Modulators Public/Granted day:2011-07-21
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