Invention Grant
- Patent Title: Coumarin derivative having antitumor activity
- Patent Title (中): 具有抗肿瘤活性的香豆素衍生物
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Application No.: US12960134Application Date: 2010-12-03
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Publication No.: US08278465B2Publication Date: 2012-10-02
- Inventor: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
- Applicant: Hitoshi Iikura , Ikumi Hyoudoh , Toshihiro Aoki , Noriyuki Furuichi , Masayuki Matsushita , Fumio Watanabe , Sawako Ozawa , Masahiro Sakaitani , Pil-Su Ho , Yasushi Tomii , Kenji Takanashi , Naoki Harada
- Applicant Address: JP Tokyo JP Kyoto
- Assignee: Chugai Seiyaku Kabushiki Kaisha,Sakai Toshiyuki
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha,Sakai Toshiyuki
- Current Assignee Address: JP Tokyo JP Kyoto
- Agency: Morgan, Lewis & Bockius, LLP
- Priority: JPP2006-032903 20060209
- Main IPC: C07D311/00
- IPC: C07D311/00

Abstract:
The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y1 and Y2 are selected from —N═ etc., Y3 and Y4 are selected from —CH═ etc., A is selected from sulfamide etc., R1 is selected from hydrogen etc., and R2 is selected from C1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.
Public/Granted literature
- US20110092700A1 Novel Coumarin Derivative Having Antitumor Activity Public/Granted day:2011-04-21
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