Invention Grant
- Patent Title: Process for preparing a benzoylbenzeneacetamide derivative
- Patent Title (中): 苯甲酰苯乙酰胺衍生物的制备方法
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Application No.: US12483839Application Date: 2009-06-12
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Publication No.: US08278484B2Publication Date: 2012-10-02
- Inventor: Gabriel Tojo Suárez , Ana Gavaldá Escudé
- Applicant: Gabriel Tojo Suárez , Ana Gavaldá Escudé
- Applicant Address: ES
- Assignee: Medichem, S.A.
- Current Assignee: Medichem, S.A.
- Current Assignee Address: ES
- Agency: Leydig. Voit & Mayer, Ltd.
- Main IPC: C07C231/12
- IPC: C07C231/12 ; C07C233/05
Abstract:
Disclosed is a process for preparing anti-inflammatory compound nepafenac comprising preparing a compound of formula (V) wherein a N-halosuccinimide is used as the halogenating agent, followed by desulfurization using Raney Nickel. Also disclosed is a polymorphic form B of 2-amino-3-benzoyl-α-(methylthio)-benzeneacetamide (i.e., a compound of formula (V) wherein R is methyl
Public/Granted literature
- US20090312575A1 Process For Preparing A Benzoylbenzeneacetamide Derivative Public/Granted day:2009-12-17
Information query
