Invention Grant
US08278499B2 Nonalcoholic steatohepatitis model rodent and fatty liver model rodent
失效
非酒精性脂肪性肝炎模型啮齿动物和脂肪肝模型啮齿动物
- Patent Title: Nonalcoholic steatohepatitis model rodent and fatty liver model rodent
- Patent Title (中): 非酒精性脂肪性肝炎模型啮齿动物和脂肪肝模型啮齿动物
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Application No.: US12308758Application Date: 2007-06-13
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Publication No.: US08278499B2Publication Date: 2012-10-02
- Inventor: Chise Mukaidani , Katsutoshi Yoshizato , Miho Kataoka
- Applicant: Chise Mukaidani , Katsutoshi Yoshizato , Miho Kataoka
- Applicant Address: JP Hiroshima JP Hiroshima JP Hiroshima
- Assignee: Hiroshima Industrial Promotion Organization,Phoenixbio Co., Ltd.,Hiroshima University
- Current Assignee: Hiroshima Industrial Promotion Organization,Phoenixbio Co., Ltd.,Hiroshima University
- Current Assignee Address: JP Hiroshima JP Hiroshima JP Hiroshima
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2006-179275 20060629
- International Application: PCT/JP2007/061943 WO 20070613
- International Announcement: WO2008/001614 WO 20080103
- Main IPC: A01K67/00
- IPC: A01K67/00 ; A01K67/027 ; G01N33/00
Abstract:
Disclosed is a nonhuman animal showing the symptoms of human nonalcoholic steatohepatitis which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal and then transplanting human hepatocytes that are propagated in the body of the chimeric nonhuman animal into an immunodeficient hepatopathic nonhuman animal of the same species as the immunodeficient hepatopathic nonhuman animal described above, as well as a nonhuman animal showing the symptoms of human fatty liver which is obtained by transplanting human hepatocytes into an immunodeficient hepatopathic nonhuman animal to produce a chimeric nonhuman animal.
Public/Granted literature
- US20090313710A1 Nonalcoholic Steatohepatitis Model Animal and Fatty Liver Model Animal Public/Granted day:2009-12-17
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