A wire-based infrastructure capable of delivering high data rates is described herein. A transmission system, reception system, and/or repeater uses wire-mapping code matrices to reduce interference in multi-wire cables to increase the data rate provided by such multi-wire cables. More particularly, code mapping matrices are applied to transmission and/or received input signals to generate a mapped signal for each output wire or corresponding to each input wire such that each mapped signal comprises a different combination of all of the input signals. Different ones of the wire-mapped signals are ultimately transmitted on different wires. In so doing, the present invention facilitates crosstalk reduction, and therefore, provides a technique that increases the data rate available on multi-wire cables.