In a method for optimizing exchanges of acknowledgement signals between a mobile equipment in asynchronous communication with a plurality of base stations of a cellular telecommunication network, the terminal sends data to the base stations and each base station is likely to return to the terminal a positive acknowledgement ACK or negative acknowledgement NACK. The method includes the steps of: synchronizing the mobile equipment with the network; and estimating quality of downlink communication between each base station and the mobile equipment on at least one standardized channel, such that if at least one base station returns an acknowledgement to the mobile equipment, the mobile equipment only requests a NACK from the base stations while the data is continuously being transmitted, and if all the base stations return a NACK to the mobile equipment, the mobile equipment only requests an ACK from the base stations during the current communication.