A method of transmitting control signals in a wireless communication system includes transmitting a first control signal via a control channel region comprising a plurality of tiles composed of a plurality of subcarriers contiguous in a frequency domain on a plurality of OFDM symbols in a time domain, and transmitting a second control signal via the control channel region, wherein the plurality of tiles included in the control channel region are distributedly or contiguously disposed within a basic range of the control channel region, a range within which the plurality of tiles are distributed in the time domain. Control channel regions can be configured in various manners, so control signals can be adaptively transmitted in various channel environments.