Systems and methods are provided for decoding signal vectors in multiple-input multiple-output (MIMO) systems, where the receiver has received one or more signal vectors from the same transmitted vector. The symbols of the received signal vectors are combined, forming a combined received signal vector that may be treated as a single received signal vector. The combined signal vector is then decoded using a maximum-likelihood decoder. In some embodiments, the combined received signal vector may be processed prior to decoding. Systems and methods are also provided for computing soft information from a combined signal vector based on a decoding metric. Computationally intensive calculations can be extracted from the critical path and implemented in preprocessors and/or postprocessors.