Aspects of a method and system for closed loop power control in wireless systems are provided. In this regard, an output power of an amplifier may be measured and an indication of the measured power may be compared to a reference signal. The results of the comparison are utilized to generate an error correction factor. The gain of a preamplifier may be adjusted utilizing the error correction factor, where the output of the preamplifier may be input to the amplifier. The error correction factor may be generated via a proportional integral derivative controller. The gain of the preamplifier may be adjusted via at least one control signal, where the at least one control signal may be generated based on a reference control word and the error correction factor. The indication of the measured power and the reference signal may be time aligned.