A three-dimensional illuminated greeting card which combines a unique card construction having a 3D pop-out structure with one or more lights contained therein. The 3D pop-out structure forms an internal cavity in which illumination means and other electronic components are contained. One or more sides of the 3D structure are made of translucent or semi-translucent material, creating a screen that can be illuminated from behind by one or more miniature lights, such as LED lights. The light or lights may be connected to an integrated circuit chip that can be programmed with various lighting effects. The greeting card may optionally include other electronic components which are configured to play sound or music or perform other electronic effects.