Invention Grant
US08283131B2 Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock
失效
用于快速测定严重脓毒症和败血性休克期间死亡风险高的患者的方法和试剂盒
- Patent Title: Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock
- Patent Title (中): 用于快速测定严重脓毒症和败血性休克期间死亡风险高的患者的方法和试剂盒
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Application No.: US12259596Application Date: 2008-10-28
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Publication No.: US08283131B2Publication Date: 2012-10-09
- Inventor: Didier Payen De La Garanderie , Anne-Claire Lukaszewicz
- Applicant: Didier Payen De La Garanderie , Anne-Claire Lukaszewicz
- Applicant Address: FR Paris
- Assignee: Assistance Publique-Hopitaux de Paris
- Current Assignee: Assistance Publique-Hopitaux de Paris
- Current Assignee Address: FR Paris
- Agency: Alston & Bird LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/533 ; G01N33/535 ; G01N33/536 ; G01N33/543 ; C07K16/24
Abstract:
The present invention provides for the in vitro establishing of a prognosis for a subject in severe sepsis with at least two organ failures or in septic shock with at least two organ failures. Embodiments of the invention comprise the steps of measuring the level of the S100A8/A9 complex from a biological sample from a subject, and comparing the measured level to a predetermined threshold in which the measured level of the S100A8/A9 complex above the predetermined threshold is indicative of a bad prognosis and a measured level of the S100A8/A9 complex below the predetermined threshold is indicative of a good prognosis.
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