Invention Grant
US08283342B2 Napadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one as agonist of the β2 adrenergic receptor
有权
5-（2 - {[6-（2,2-二氟-2-苯基乙氧基）己基]氨基} -1-羟基乙基）-8-羟基喹啉-2（1H） - 酮的二硬脂酸盐作为 肾上腺素能受体
![Napadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one as agonist of the β2 adrenergic receptor](/docs/US/2012-10-09/US08283342B2/abs.jpg.600x600.jpg)
- Patent Title: Napadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one as agonist of the β2 adrenergic receptor
- Patent Title (中): 5-（2 - {[6-（2,2-二氟-2-苯基乙氧基）己基]氨基} -1-羟基乙基）-8-羟基喹啉-2（1H） - 酮的二硬脂酸盐作为 肾上腺素能受体
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Application No.: US12526090Application Date: 2008-02-08
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Publication No.: US08283342B2Publication Date: 2012-10-09
- Inventor: Carlos Puig Duran , Enrique Moyes Valls
- Applicant: Carlos Puig Duran , Enrique Moyes Valls
- Applicant Address: ES Barcelona
- Assignee: Almirall S.A.
- Current Assignee: Almirall S.A.
- Current Assignee Address: ES Barcelona
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- Priority: ES200700362 20070209
- International Application: PCT/EP2008/000975 WO 20080208
- International Announcement: WO2008/095720 WO 20080814
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A01N45/00 ; A61K31/44 ; A61K31/56 ; A61K9/14 ; C07D215/00
![Napadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one as agonist of the β2 adrenergic receptor](/abs-image/US/2012/10/09/US08283342B2/abs.jpg.150x150.jpg)
Abstract:
The present disclosure relates to crystalline monoapadisylate and/or heminapadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, and pharmaceutically acceptable solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the crystalline monoapadisylate and/or heminapadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, and to methods of treatment comprising these pharmaceutical compositions.
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