Invention Grant
US08283441B2 Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases
有权
Na + K + -ATP酶特异性肽抑制剂/ SRC和SRC家族激酶的激活剂
- Patent Title: Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases
- Patent Title (中): Na + K + -ATP酶特异性肽抑制剂/ SRC和SRC家族激酶的激活剂
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Application No.: US12446856Application Date: 2007-10-31
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Publication No.: US08283441B2Publication Date: 2012-10-09
- Inventor: Zijian Xie , Joseph I. Shapiro , Jiang Tian
- Applicant: Zijian Xie , Joseph I. Shapiro , Jiang Tian
- Applicant Address: US OH Toledo
- Assignee: University of Toledo
- Current Assignee: University of Toledo
- Current Assignee Address: US OH Toledo
- Agency: MacMillan, Sobanski & Todd, LLC
- International Application: PCT/US2007/023011 WO 20071031
- International Announcement: WO2008/054792 WO 20080508
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K14/00
Abstract:
A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
Public/Granted literature
- US20100056446A1 NA+K+-ATPase-Specific Peptide Inhibitors/Activators of SRC and SRC Family Kinases Public/Granted day:2010-03-04
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