Invention Grant
US08283474B2 Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors 有权
可用作多巴胺D3受体调节剂的氮杂双环(3.1.0)己烷衍生物

  • Patent Title: Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors
  • Patent Title (中): 可用作多巴胺D3受体调节剂的氮杂双环(3.1.0)己烷衍生物
  • Application No.: US12639282
    Application Date: 2009-12-16
  • Publication No.: US08283474B2
    Publication Date: 2012-10-09
  • Inventor: Anna Maria CapelliGiovanna Tedesco
  • Applicant: Anna Maria CapelliGiovanna Tedesco
  • Applicant Address: GB Greenford, Middlesex
  • Assignee: Glaxo Group Limited
  • Current Assignee: Glaxo Group Limited
  • Current Assignee Address: GB Greenford, Middlesex
  • Agent Bonnie L. Deppenbrock
  • Priority: GB0403990.5 20040223; GB0404083.8 20040224; GB0417120.3 20040730
  • Main IPC: C07D215/38
  • IPC: C07D215/38
Azabicyclo (3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors
Abstract:
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein G is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl, indazolyl; p is an integer ranging from 0 to 5; R1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl; or corresponds to a group R5; R2 is hydrogen or C1-4alkyl; R3 is C1-4alkyl; R4 is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; R5 is a moiety selected from the group consisting of: isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such a group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; and when R1 is chlorine and p is 1, such R1 is not present in the ortho position with respect to the linking bond to the rest of the molecule; and when R1 corresponds to R5, p is 1; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency or as antipsychotic agents.
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