Geographically dispersed data centers each include servers and storage systems and are in communication with each other. An application is installed on a guest operating system on a virtual machine set up on a server at a first data center. The application accesses a logical unit on a storage system at the first data center. When migration of the application is initiated, the process determines whether any of the data centers has server resources and storage resources required to receive migration of the application. A destination data center is selected from candidate data centers meeting requirements for migration of the application. The application and guest operating system are migrated from the first data center to a second virtual machine set up on a second server at the destination data center. If a replica of the LU is not already present at the destination data center, the LU is also replicated.