Invention Grant
- Patent Title: Integrated finite element and circulatory model for predicting hemodynamic effects of left ventricular impairment, resynchronization and remodeling
- Patent Title (中): 综合有限元和循环模型预测左心室损伤,再同步和重塑的血液动力学影响
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Application No.: US11778231Application Date: 2007-07-16
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Publication No.: US08295907B2Publication Date: 2012-10-23
- Inventor: Ying Sun , Frederick J. Vetter , Rumei Dong , Salvatore A. Chiaramida
- Applicant: Ying Sun , Frederick J. Vetter , Rumei Dong , Salvatore A. Chiaramida
- Applicant Address: US RI Providence
- Assignee: Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
- Current Assignee: Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
- Current Assignee Address: US RI Providence
- Agency: Gesmer Updegrove LLP
- Main IPC: A61B5/05
- IPC: A61B5/05

Abstract:
A computational model which integrates a complex circulatory model and a finite element to determine the dynamics of a left ventricle continuously over consecutive cardiac cycles. The model includes determining a LV pressure (plv) using a circulatory model, using a finite element model plv as input and determining a LV volume (vlv), computing a LV elastance according to: elv=plv/vlv, driving the circulatory model with the elv; and returning to determining a LV pressure and starting the next iteration, wherein the steps continue at a sufficient time resolution for a desired number of entire cardiac cycles. The dynamic Young's modulus functions are assigned to individual finite elements, resulting in a time-varying left ventricular elastance that drives the circulatory model.
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