A locking assembly for a door having an outer side, an inner side and a sidewall and has an exterior assembly, a cylinder and an interior assembly. The exterior assembly is mounted on the outer side of the door and has an outside mounting seat, a press-button, a transmitting device, a transmitting board, an engaging wheel and a rotating spindle. The cylinder is mounted in the exterior assembly and has a cylinder-transmitting panel. The multi-point latch is mounted in the sidewall of the door and is connected to the exterior assembly and the cylinder. The interior assembly is mounted on the inner side of the door, is connected to the exterior assembly and the cylinder and has an inside mounting seat, a operating handle, a switch, a linking device, a seat board, an inside reset spring and a switch mount.