A method for controlling the flow of a multiphase fluid from a well extending into a subsurface formation, which well is provided at a downstream position with a valve having a variable aperture, which method comprises allowing the multiphase fluid to flow at a selected aperture of the valve; selecting a flow parameter of the multiphase fluid, which flow parameter is responsive to changes in a gas/liquid ratio of the multiphase fluid at an upstream position in the well, and a setpoint for the flow parameter; and monitoring the flow parameter; controlling the flow parameter towards its setpoint by manipulating the aperture of the valve; wherein the control time between detection of a deviation from the setpoint and the manipulation of the aperture is shorter than the time needed for the multiphase fluid to travel 25% of the distance between the upstream and downstream positions. Further a well extending into a subsurface formation for producing a multiphase fluid to surface, which well is provided at a downstream position with a valve having a variable aperture, and with a control system for controlling the multiphase flow.