Methods and systems of forming barbed sutures from blown films are provided. A method for forming a barbed suture includes providing a blown film, cutting slits into an outer edge of the blown film, and twisting the blown film such that the slits protrude from the twisted blown film to form a barbed suture. A system for forming a barbed suture includes a set of heating rollers configured for stiffening an outer edge of a blown film, a set of cutting rollers configured for forming slits in the outer edge, a set of twisting rollers configured for twisting the blown film into a suture, and a heat source to set the suture.