Invention Grant
US08303935B2 Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid
失效
具有对淀粉样蛋白亲和力的烷氧基取代的咪唑并[1,2-a]吡啶
- Patent Title: Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid
- Patent Title (中): 具有对淀粉样蛋白亲和力的烷氧基取代的咪唑并[1,2-a]吡啶
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Application No.: US12227487Application Date: 2007-05-15
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Publication No.: US08303935B2Publication Date: 2012-11-06
- Inventor: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- Applicant: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- Applicant Address: JP Tokyo
- Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fitch, Even, Tabin & Flannery, LLP
- Priority: JP2006-140044 20060519; JP2006-324701 20061130
- International Application: PCT/JP2007/059922 WO 20070515
- International Announcement: WO2007/135890 WO 20071129
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14
![Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid](/abs-image/US/2012/11/06/US08303935B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagencity. Provided is a compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represents a carbon or nitrogen; R1 is a halogen substituent; R2 is a halogen substituent; and m is an integer of 0 to 2, provided that at least one of R1 and R2 is a radioactive halogen substituent, at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4 as well as a low-toxic diagnostic agent comprising a compound represented by the preceding formula or a salt thereof.
Public/Granted literature
- US20090252679A1 Novel Compound Having Affinity for Amyloid Public/Granted day:2009-10-08
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