Invention Grant
US08303963B2 Methylated heparin-binding hemagglutinin recombinant mycobacterial antigen, preparation method and immunogenic compositions comprising same
有权
甲基化肝素结合血凝素重组分枝杆菌抗原，制备方法和包含其的免疫原性组合物
- Patent Title: Methylated heparin-binding hemagglutinin recombinant mycobacterial antigen, preparation method and immunogenic compositions comprising same
- Patent Title (中): 甲基化肝素结合血凝素重组分枝杆菌抗原，制备方法和包含其的免疫原性组合物
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Application No.: US12895185Application Date: 2010-09-30
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Publication No.: US08303963B2Publication Date: 2012-11-06
- Inventor: Kevin Pethe , Franco Menozzi , Camille Locht
- Applicant: Kevin Pethe , Franco Menozzi , Camille Locht
- Applicant Address: FR Lille Cedex FR Paris Cedex
- Assignee: Institut Pasteur de Lille,Unstitut National de la Sante et de la Rechereche Medicale
- Current Assignee: Institut Pasteur de Lille,Unstitut National de la Sante et de la Rechereche Medicale
- Current Assignee Address: FR Lille Cedex FR Paris Cedex
- Agency: Birch, Stewart, Kolasch & Birch, LLP.
- Priority: FR0114953 20011119
- Main IPC: A61K39/04
- IPC: A61K39/04 ; A61K39/02 ; A61K49/00
Abstract:
The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, the sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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