Invention Grant
- Patent Title: Identification of a micro-RNA that activates expression of β-myosin heavy chain
- Patent Title (中): 鉴定激活肌球蛋白重链表达的微RNA
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Application No.: US11831427Application Date: 2007-07-31
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Publication No.: US08304397B2Publication Date: 2012-11-06
- Inventor: Eric Olson , Eva Van Rooij
- Applicant: Eric Olson , Eva Van Rooij
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Cooley LLP
- Main IPC: A61K35/00
- IPC: A61K35/00 ; A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of β-myosin heavy chain (β-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.
Public/Granted literature
- US20090180957A1 IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN Public/Granted day:2009-07-16
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