Invention Grant
- Patent Title: Process for stereoselective synthesis of lamivudine
- Patent Title (中): 立体选择性合成拉米夫定的方法
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Application No.: US12619830Application Date: 2009-11-17
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Publication No.: US08304540B2Publication Date: 2012-11-06
- Inventor: Jinliang Li , Feng Lv
- Applicant: Jinliang Li , Feng Lv
- Applicant Address: CN Shanghai
- Assignee: Shanghai Desano Pharmaceutical Holding Co., Ltd.
- Current Assignee: Shanghai Desano Pharmaceutical Holding Co., Ltd.
- Current Assignee Address: CN Shanghai
- Agency: Dorsey & Whitney LLP
- Priority: CN200710040912 20070518
- Main IPC: C07D411/04
- IPC: C07D411/04
Abstract:
The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.
Public/Granted literature
- US20110118465A2 PROCESS FOR STEREOSELECTIVE SYNTHESIS OF LAMIVUDINE Public/Granted day:2011-05-19
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