Invention Grant
- Patent Title: Azolecarboxamide compound or salt thereof
- Patent Title (中): 偶氮甲酰胺化合物或其盐
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Application No.: US12739433Application Date: 2008-10-23
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Publication No.: US08304547B2Publication Date: 2012-11-06
- Inventor: Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
- Applicant: Keizo Sugasawa , Kenichi Kawaguchi , Takaho Nomura , Shunichiro Matsumoto , Takashi Shin , Hidenori Azami , Tomoaki Abe , Akira Suga , Ryushi Seo , Masayuki Tanahashi , Toru Watanabe
- Applicant Address: JP Tokyo
- Assignee: Astellas Pharma Inc.
- Current Assignee: Astellas Pharma Inc.
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2007276894 20071024
- International Application: PCT/JP2008/069263 WO 20081023
- International Announcement: WO2009/054468 WO 20090430
- Main IPC: C07D211/68
- IPC: C07D211/68 ; C07D221/20 ; C07D491/20 ; C07D413/14 ; C07D239/09 ; A61K31/535 ; A61K31/505 ; A61K31/44 ; A61K31/445

Abstract:
[Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, based on an excellent trkA receptor inhibitory action.[Means for Solution] A novel azolecarboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof is confirmed to have a potent trkA receptor inhibitory activity, and found to be capable of being used as a therapeutic and/or prophylactic agent which is excellent in efficacy and safety for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, thereby completing the present invention.
Public/Granted literature
- US20100249088A1 AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF Public/Granted day:2010-09-30
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