A latch-control protection circuit applied in a power converter is provided. The protection circuit has a comparing circuit unit and a logic gate. The comparing circuit unit is utilized to selectively output a default signal or a comparing signal according to a state signal from the logic gate, wherein the default signal is utilized for latching the state signal and the comparing signal is corresponded to the power condition of the power converter. The logic gate generates the state signal according to the output signal of the comparing circuit unit and a system judging signal. The output signal may be the default signal or the comparing signal. The system judging signal indicates the condition of the power converter.