A system for determining a patient benefits eligibility under a healthcare assistance program. Initial patient information, such as the patient's date of birth, household members, medical condition including pregnancy, and income and financial resources, if available, is used to make an initial determination as to whether the patient is likely to qualify for benefits. If the initial patient information satisfies one of the well-established criteria or the probability models, additional patient information is obtained, typically including additional details about the patient's income and financial resources, as well as the income and financial resources of the patient's household. The patient information is compared to the eligibility requirements for the assistance program. If the comparison indicates that it is likely that the patient will qualify for benefits under the assistance program, then an application for the assistance program is provided and the application is completed and submitted.