A cluster manager is configured to manage a plurality of copies of a mid-tier database as a mid-tier database cluster. The cluster manager may concurrently manage a backend database system. The cluster manager is configured to monitor for and react to failures of mid-tier database nodes. The cluster manager may react to a mid-tier database failure by, for example, assigning a new active node, creating a new standby node, creating new copies of the mid-tier databases, implementing new replication or backup schemes, reassigning the node's virtual address to another node, or relocating applications that were directly linked to the mid-tier database to another host. Each node or an associated agent may configure the cluster manager to behave in this fashion during initialization, based on common cluster configuration information. Each copy of the mid-tier database may be, for example, a memory resident database. Thus, a node must reload the entire database into memory to recover a copy of the database.