A system that uses segmentation to safely execute native code. This system includes a processing element that executes the native code and a memory which stores code and data for the processing element. The processing element includes a segmentation mechanism which limits the native code executing on the processing element to accessing a specified segment of memory. The processing element also includes an instruction-processing unit, which is configured to execute a user-level instruction that causes the segmentation mechanism to limit memory accesses by the native code to the specified segment of the memory.