The number of battery cells connected together in a main battery conductor path of a multiple cell battery system of an information handling system may be varied in real time based on one or more operating conditions (e.g., system load power consumption, battery cell failure, etc.) of the information handling system. Defective battery cells may be bypassed such that the defective battery system may continue to operate and power an information handling system at a lower voltage, e.g., either temporarily, permanently or temporarily until the user procures a suitable replacement battery system. Interconnection of cells of a non-defective multiple cell battery system may also be selectively re-arranged to vary battery system voltage at particular times or during particular information handling system operation modes.