Invention Grant
US08314233B2 Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters
有权
制备2-(氨基亚甲基)-4,4-二氟-3-氧代丁酸酯的方法
- Patent Title: Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters
- Patent Title (中): 制备2-(氨基亚甲基)-4,4-二氟-3-氧代丁酸酯的方法
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Application No.: US12990359Application Date: 2009-04-30
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Publication No.: US08314233B2Publication Date: 2012-11-20
- Inventor: Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
- Applicant: Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Brinks Hofer Gilson & Lione
- Priority: EP08155612 20080502
- International Application: PCT/EP2009/055283 WO 20090430
- International Announcement: WO2009/133178 WO 20091105
- Main IPC: C07D295/145
- IPC: C07D295/145 ; C07D211/34 ; C07D265/30

Abstract:
The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters, 2-(aminomethylidene)-4,4-difluoro-3-oxobutteric esters of the formula (I) in which R1, R2 and R3 independently of one another are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl or NR2R3 is a 5- to 10-membered heterocyclic radical, to a process for preparing compounds of the formula (I) wherein an appropriate 3-aminoacrylic ester is reacted with difluoroacetyl fluoride and to the use of compounds of the formula (I) in the process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.
Public/Granted literature
- US20110046371A1 PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS Public/Granted day:2011-02-24
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