Invention Grant
- Patent Title: Process for the preparation of synthetic taxanes
- Patent Title (中): 合成紫杉烷的制备方法
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Application No.: US10585794Application Date: 2005-01-17
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Publication No.: US08314261B2Publication Date: 2012-11-20
- Inventor: Dingning Tang , Jian Li
- Applicant: Dingning Tang , Jian Li
- Applicant Address: CN Guilin
- Assignee: Guilin Huiang Biochemistry Pharmaceutical Co. Ltd.
- Current Assignee: Guilin Huiang Biochemistry Pharmaceutical Co. Ltd.
- Current Assignee Address: CN Guilin
- Agency: Weaver Austin Villeneuve & Sampson LLP
- Priority: CN200410021751 20040116
- International Application: PCT/CN2005/000068 WO 20050117
- International Announcement: WO2005/073209 WO 20050811
- Main IPC: C07D407/00
- IPC: C07D407/00

Abstract:
The present invention relates to a process for the preparation of synthetic taxanes, which protects C(7)-OH with lanthanon compounds. Its advantages are simple process and firm & reliable binding. Moreover, no C(7)-acylated taxanes are produced in the subsequent steps, and hydrolysis of C(2′)-ester groups in acylated products becomes readily controllable. In the process for the preparation of synthetic taxanes, tetrahydrofuran is used in the present invention as a medium for acylation, which not only achieves the same effects as pyridine, but also avoids odor, so as to solve the problem regarding the extremely high requirements for the place of production. The present invention can be used for the preparation of not only semi-synthetic taxane using natural taxanes as raw material, but also full-synthetic taxane.
Public/Granted literature
- US20080287696A1 Process for the Preparation of Synthetic Taxanes Public/Granted day:2008-11-20
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