According to one aspect of the invention, a force measurement system includes a force measurement assembly, a motion base configured to displace the force measurement assembly, and an inertial compensation system configured to determine the inertial forces and/or moments resulting from the displacement of the force measurement assembly by the motion base. According to another aspect of the invention, a method for accurately determining the forces and/or moments applied to a surface of a force measurement device by a subject disposed thereon is disclosed, which includes the step of determining, by using an inertial compensation system, the inertial forces and/or moments resulting from the displacement of a force measurement assembly by a motion base. According to still another aspect of the invention, a force and/or motion measurement system having inertial compensation includes a motion acquisition system having a plurality of motion sensing devices configured to capture a subject's movement.