Invention Grant
US08323269B2 Metronomic convection enhanced delivery of intrathecal chemotherapy using an implanted magnetic breather pump (MBP) for leptomeningeal carcinomatosis
有权
使用植入式磁通呼吸泵(MBP)进行脑膜瘤化疗的Metronomic对流增强输送用于脑膜炎
- Patent Title: Metronomic convection enhanced delivery of intrathecal chemotherapy using an implanted magnetic breather pump (MBP) for leptomeningeal carcinomatosis
- Patent Title (中): 使用植入式磁通呼吸泵(MBP)进行脑膜瘤化疗的Metronomic对流增强输送用于脑膜炎
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Application No.: US12581756Application Date: 2009-10-19
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Publication No.: US08323269B2Publication Date: 2012-12-04
- Inventor: Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Bruce Marx , David Johnson , Laszlo Farkas
- Applicant: Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Bruce Marx , David Johnson , Laszlo Farkas
- Applicant Address: US CA Inglewood
- Assignee: Pharmaco-Kinesis Corporation
- Current Assignee: Pharmaco-Kinesis Corporation
- Current Assignee Address: US CA Inglewood
- Agent Marcus C. Dawes; Daniel L. Dawes
- Main IPC: A61K9/22
- IPC: A61K9/22

Abstract:
A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled lumen, intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
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