Invention Grant
- Patent Title: Adenoviral vector-based foot-and-mouth disease vaccine
- Patent Title (中): 基于腺病毒载体的口蹄疫疫苗
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Application No.: US12117513Application Date: 2008-05-08
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Publication No.: US08323663B2Publication Date: 2012-12-04
- Inventor: Douglas E. Brough , Joseph T. Bruder , C. Richter King , Marvin J. Grubman , John G. Neilan
- Applicant: Douglas E. Brough , Joseph T. Bruder , C. Richter King , Marvin J. Grubman , John G. Neilan
- Applicant Address: US MD Gaithersburg
- Assignee: GenVec, Inc.
- Current Assignee: GenVec, Inc.
- Current Assignee Address: US MD Gaithersburg
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: A61K39/23
- IPC: A61K39/23 ; A61K39/285
Abstract:
The invention is directed to an adenoviral vector comprising at least one nucleic acid sequence encoding an aphthovirus antigen and/or a cytokine operably linked to a promoter. The adenoviral vector is replication-deficient and requires at most complementation of both the E1 region and the E4 region of the adenoviral genome for propagation. The invention also is directed to a method of inducing an immune response in a mammal comprising administering to the mammal a composition comprising the aforementioned adenoviral vector.
Public/Granted literature
- US20090264509A1 Adenoviral vector-based foot-and-mouth disease vaccine Public/Granted day:2009-10-22
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