Invention Grant
- Patent Title: Preparation of regulatory T cells using ICAM-1 co-stimulation
- Patent Title (中): 使用ICAM-1共同刺激制备调节性T细胞
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Application No.: US12122377Application Date: 2008-05-16
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Publication No.: US08323969B2Publication Date: 2012-12-04
- Inventor: Stephen H. Benedict , Kelli M. Cool , Abby L. Dotson
- Applicant: Stephen H. Benedict , Kelli M. Cool , Abby L. Dotson
- Applicant Address: US KS Lawrence
- Assignee: University of Kansas
- Current Assignee: University of Kansas
- Current Assignee Address: US KS Lawrence
- Agency: Stinson Morrison Hecker LLP
- Main IPC: C12N5/071
- IPC: C12N5/071 ; C12N5/00 ; C12N5/02
Abstract:
A method for generating a purified regulatory T cell composition having a CD4+CD25+Foxp3− phenotype from naive T cells having CD4+CD45RA+RO−CD11alo CD27+ phenotype comprising the steps of stimulating a T cell receptor on the naive T cells and stimulating ICAM-1 on the naive T cells.
Public/Granted literature
- US20080286245A1 PREPARATION OF REGULATORY T CELLS USING ICAM-1 CO-STIMULATION Public/Granted day:2008-11-20
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