Invention Grant
US08324385B2 Diacylglycerol acyltransferase inhibitors 有权
二酰基甘油酰基转移酶抑制剂

Diacylglycerol acyltransferase inhibitors
Abstract:
Provided herein are compounds of the formula (I): were RI is phenyl, R2 is hydrogen, halogen or lower alkyl, X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a -4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of trigliceride. such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
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