Invention Grant
- Patent Title: Diacylglycerol acyltransferase inhibitors
- Patent Title (中): 二酰基甘油酰基转移酶抑制剂
-
Application No.: US12581950Application Date: 2009-10-20
-
Publication No.: US08324385B2Publication Date: 2012-12-04
- Inventor: David Robert Bolin , Adrian Wai-Hing Cheung , Matthew Michael Hamilton , Nicholas Marcopulos , Lee Apostle McDermott , Yimin Qian
- Applicant: David Robert Bolin , Adrian Wai-Hing Cheung , Matthew Michael Hamilton , Nicholas Marcopulos , Lee Apostle McDermott , Yimin Qian
- Applicant Address: US PA Fort Washington
- Assignee: Madrigal Pharmaceuticals, Inc.
- Current Assignee: Madrigal Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ivor R. Elrifi; Heidi A. Erlacher
- Main IPC: C07D401/00
- IPC: C07D401/00 ; C07D403/00 ; C07D405/00 ; C07D409/00

Abstract:
Provided herein are compounds of the formula (I): were RI is phenyl, R2 is hydrogen, halogen or lower alkyl, X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a -4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of trigliceride. such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
Public/Granted literature
- US20100113782A1 Diacylglycerol Acyltransferase Inhibitors Public/Granted day:2010-05-06
Information query